Influence of Caloric Restriction on Ageing
نویسندگان
چکیده
منابع مشابه
Overview of caloric restriction and ageing.
It has been known for some 70 years that restricting the food intake of laboratory rats extends their mean and maximum life span. In addition, such life extension has been observed over the years in many other species, including mice, hamsters, dogs, fish, invertebrate animals, and yeast. Since this life-extending action appears to be due to a restricted intake of energy, this dietary manipulat...
متن کاملCaloric restriction delays cardiac ageing in rats: role of mitochondria.
AIMS We tested whether long-term caloric restriction (CR) corrects pre-existing manifestations of cardiac ageing in rats. METHODS AND RESULTS The age-specific effects of CR (-40%, 6 months) on mortality, left ventricular (LV) function, mitochondrial function, oxidative damage, and apoptosis were analysed in young (6 + 6 months) and senescent rats (24 + 6 months). CR in senescent rats signific...
متن کاملAgeing and Caloric Restriction in a Marine Planktonic Copepod
Planktonic copepods are a key group in the marine pelagic ecosystem, linking primary production with upper trophic levels. Their abundance and population dynamics are constrained by the life history tradeoffs associated with resource availability, reproduction and predation pressure. The tradeoffs associated with the ageing process and its underlying biological mechanisms are, however, poorly k...
متن کامل[Effect of caloric restriction on longevity].
Calorie restriction (CR) is the most evaluated nutritional intervention to increase lifespan in a variety of animal species, including human beings. CR has also been shown to delay the onset or reduce the incidence of many age-related diseases. The mechanism that could explain the effect of calorie intake on aging is related to the reduction of body fat and insulin signaling as well as reactive...
متن کاملCaloric restriction in humans.
Studies on mice and rats have demonstrated that calorie restriction (CR) slows primary aging, has a protective effect against secondary aging, and markedly decreases the incidence of malignancies. However, the only way to determine whether CR "works" in humans is to conduct studies on people. Such studies are difficult to perform in free-living people. While research on CR in humans is still at...
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ژورنال
عنوان ژورنال: Revista Portuguesa de Endocrinologia, Diabetes e Metabolismo
سال: 1999
ISSN: 1646-3439
DOI: 10.26497/ar190007